The TERT rs2736100 polymorphism and cancer risk: a meta-analysis based on 25 case-control studies.

ABSTRACT:

Background

The association between the TERT rs2736100 single nucleotide polymorphism (SNP) and cancer risk has been studied by many researchers, but the results remain inconclusive. To further explore this association, we performed a meta-analysis.

Methods

A computerized search of PubMed and Embase database for publications on the TERT rs2736100 polymorphism and cancer risk was performed and the genotype data were analyzed in a meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association. Sensitivity analysis, test of heterogeneity, cumulative meta-analysis and assessment of bias were performed in our meta-analysis.

Results

A significant association between the TERT rs2736100 polymorphism and cancer susceptibility was r

SUBMITTER: Zou P 

PROVIDER: S-EPMC3329415 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature