Unique profile of ordered arrangements of repetitive elements in the C57BL/6J mouse genome implicating their functional roles.

ABSTRACT: The entirety of all protein coding sequences is reported to represent a small fraction (~2%) of the mouse and human genomes; the vast majority of the rest of the genome is presumed to be repetitive elements (REs). In this study, the C57BL/6J mouse reference genome was subjected to an unbiased RE mining to establish a whole-genome profile of RE occurrence and arrangement. The C57BL/6J mouse genome was fragmented into an initial set of 5,321 units of 0.5 Mb, and surveyed for REs using unbiased self-alignment and dot-matrix protocols. The survey revealed that individual chromosomes had unique profiles of RE arrangement structures, named RE arrays. The RE populations in certain genomic regions were arranged into various forms of complexly organized structures using combinations of direct and/o

SUBMITTER: Lee YK 

PROVIDER: S-EPMC3329453 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature