Up-regulated expression of extracellular matrix remodeling genes in phagocytically challenged trabecular meshwork cells.

ABSTRACT:

Background

Cells in the trabecular meshwork (TM), the tissue responsible for draining aqueous humor out of the eye, are known to be highly phagocytic. Phagocytic function in TM cells is thought to play an important role in the normal functioning of the outflow pathway. Dysfunction of phagocytosis could lead to abnormalities of outflow resistance and increased intraocular pressure (IOP). However, the molecular mechanisms triggered by phagocytosis in TM cells are completely unknown.

Methodology/principal findings

Gene expression profile analysis of human TM cells phagocytically challenged to E. coli or pigment under physiological and oxidative stress environment were performed using Affymetrix U133 plus 2.0 array and analyzed with Genespring GX. Despite the differential biolog

SUBMITTER: Porter KM 

PROVIDER: S-EPMC3329506 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature