Genetics and genomics in pediatric septic shock.

ABSTRACT:

Objectives

Pediatric septic shock continues to be an important public health problem. Several investigative groups have applied genetic and genomic approaches as a means of identifying novel pathways and therapeutic targets, discovery of sepsis-related biomarkers, and identification of septic shock subclasses. This review will highlight studies in pediatric sepsis with a focus on gene association studies and genome-wide expression profiling.

Data sources

A summary of published literature involving gene association and expression profiling studies specifically involving pediatric sepsis and septic shock.

Summary

Several polymorphisms of genes broadly involved in inflammation, immunity, and coagulation have been linked with susceptibility to sepsis, or outcome of sepsis

SUBMITTER: Wong HR 

PROVIDER: S-EPMC3329642 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature