Integrative set enrichment testing for multiple omics platforms.

ABSTRACT:

Background

Enrichment testing assesses the overall evidence of differential expression behavior of the elements within a defined set. When we have measured many molecular aspects, e.g. gene expression, metabolites, proteins, it is desirable to assess their differential tendencies jointly across platforms using an integrated set enrichment test. In this work we explore the properties of several methods for performing a combined enrichment test using gene expression and metabolomics as the motivating platforms.

Results

Using two simulation models we explored the properties of several enrichment methods including two novel methods: the logistic regression 2-degree of freedom Wald test and the 2-dimensional permutation p-value for the sum-of-squared statistics test. In relation

SUBMITTER: Poisson LM 

PROVIDER: S-EPMC3329720 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature