Progressive structural brain changes during development of psychosis.

ABSTRACT:

Background

Ultra-high risk (UHR) for psychosis has been associated with widespread structural brain changes in young adults. The onset of these changes and their subsequent progression over time are not well understood.

Methods

Rate of brain change over time was investigated in 43 adolescents at UHR for psychosis compared with 30 healthy controls. Brain volumes (total brain, gray matter, white matter [WM], cerebellum, and ventricles), cortical thickness, and voxel-based morphometry were measured at baseline and at follow-up (2 y after baseline) and compared between UHR individuals and controls. Post hoc analyses were done for UHR individuals who became psychotic (N = 8) and those who did not (N = 35).

Results

UHR individuals showed a smaller increase in cerebral WM ov

SUBMITTER: Ziermans TB 

PROVIDER: S-EPMC3329986 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature