Disease and genetic contributions toward local tissue volume disturbances in schizophrenia: a tensor-based morphometry study.

ABSTRACT: Structural brain deficits, especially frontotemporal volume reduction and ventricular enlargement, have been repeatedly reported in patients with schizophrenia. However, it remains unclear whether brain structural deformations may be attributable to disease-related or genetic factors. In this study, the structural magnetic resonance imaging data of 48 adult-onset schizophrenia patients, 65 first-degree nonpsychotic relatives of schizophrenia patients, 27 community comparison (CC) probands, and 73 CC relatives were examined using tensor-based morphometry (TBM) to isolate global and localized differences in tissue volume across the entire brain between groups. We found brain tissue contractions most prominently in frontal and temporal regions and expansions in the putamen/pallidum, and later

SUBMITTER: Yang Y 

PROVIDER: S-EPMC3330198 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature