Comparison of cognitive decline between dementia with Lewy bodies and Alzheimer's disease: a cohort study.

ABSTRACT:

Objectives

Dementia with Lewy bodies (DLB) accounts for 10%-15% of dementia cases at autopsy and has distinct clinical features associated with earlier institutionalisation and a higher level of carer distress than are seen in Alzheimer's disease (AD). At present, there is on-going debate as to whether DLB is associated with a more rapid cognitive decline than AD. An understanding of the rate of decline of cognitive and non-cognitive symptoms in DLB may help patients and carers to plan for the future.

Design

In this cohort study, the authors compared 100 AD and 58 DLB subjects at baseline and at 12-month follow-up on cognitive and neuropsychiatric measures.

Setting

Patients were recruited from 40 European centres.

Participants

Subjects with mild-moderate dement

SUBMITTER: Walker Z 

PROVIDER: S-EPMC3330257 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature