Similar requirements for CDC-42 and the PAR-3/PAR-6/PKC-3 complex in diverse cell types.

ABSTRACT: During animal development, a complex of Par3, Par6 and atypical protein kinase C (aPKC) plays a central role in cell polarisation. The small G protein Cdc42 also functions in cell polarity and has been shown in some cases to act by regulating the Par3 complex. However, it is not yet known whether Cdc42 and the Par3 complex widely function together in development or whether they have independent functions. For example, many studies have implicated Cdc42 in cell migrations, but the Par3 complex has only been little studied, with conflicting results. Here we examine the requirements for CDC-42 and the PAR-3/PAR-6/PKC-3 complex in a range of different developmental events. We found similar requirements in all tissues examined, including polarised growth of vulval precursors and seam cells, mig

SUBMITTER: Welchman DP 

PROVIDER: S-EPMC3330270 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature