Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study.

ABSTRACT:

Background

In this prospective cohort study, we have undertaken a comprehensive evaluation of clinical parameters along with variation in 29 genes (including CYP2C9 and VKORC1) to identify factors determining interindividual variability in warfarin response.

Methods

Consecutive patients (n=311) were followed up prospectively for 26 weeks. Several outcomes chosen to capture both warfarin efficacy and toxicity were assessed. Univariate and multiple regression analyses were undertaken to assess the combined effect of clinical and genetic factors.

Results

CYP2C9 was the most important gene determining initial anticoagulant control, whereas VKORC1 was more important for stable anticoagulation. Novel associations with some clinical outcomes were found with single nucleotide

SUBMITTER: Jorgensen AL 

PROVIDER: S-EPMC3330749 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature