A line of mice selected for high blood ethanol concentrations shows drinking in the dark to intoxication.

ABSTRACT:

Background

Many animal models of alcoholism have targeted aspects of excessive alcohol intake (abuse) and dependence. In the rodent, models aimed at increasing alcohol self-administration have used genetic or environmental manipulations, or their combination. Strictly genetic manipulations (e.g., comparison of inbred strains or targeted mutants, selective breeding) have not yielded rat or mouse genotypes that will regularly and voluntarily drink alcohol to the point of intoxication. Although some behavioral manipulations (e.g., scheduling or limiting access to alcohol, adding a sweetener) will induce mice or rats to drink enough alcohol to become intoxicated, these typically require significant food or water restriction or a long time to develop. We report progress toward the devel

SUBMITTER: Crabbe JC 

PROVIDER: S-EPMC3330756 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature