Cell adhesion molecule mediation of myocardial inflammatory responses associated with ventricular pacing.

ABSTRACT: Poorly synchronized activation of the ventricles can lead to impairment of normal cardiac structure/function. We reported previously that short term (4 h) left ventricular (LV) pacing-induced ventricular dyskinesis led to an inflammatory response localized to the epicardium. Results from this study demonstrated that neutrophils may play a major role in this inflammatory process. Neutrophil recruitment to a site of injury is a process that is highly dependent on an upregulation of cell adhesion molecules (CAM). The dependence of ventricular dysynchrony-induced inflammatory responses on CAM upregulation has not been explored. To gain further insight, we used a mouse model of LV pacing to evaluate the role of CAM in mediating the inflammatory response associated with ventricular dyskinesis. W

SUBMITTER: Yamazaki KG 

PROVIDER: S-EPMC3330786 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature