The RNA-binding protein human antigen R controls global changes in gene expression during Schwann cell development.

ABSTRACT: An important prerequisite to myelination in peripheral nerves is the establishment of one-to-one relationships between axons and Schwann cells. This patterning event depends on immature Schwann cell proliferation, apoptosis, and morphogenesis, which are governed by coordinated changes in gene expression. Here, we found that the RNA-binding protein human antigen R (HuR) was highly expressed in immature Schwann cells, where genome-wide identification of its target mRNAs in vivo in mouse sciatic nerves using ribonomics showed an enrichment of functionally related genes regulating these processes. HuR coordinately regulated expression of several genes to promote proliferation, apoptosis, and morphogenesis in rat Schwann cells, in response to NRG1, TGFβ, and laminins, three major signals implic

SUBMITTER: Iruarrizaga-Lejarreta M 

PROVIDER: S-EPMC3331722 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature