Peripheral blood monocyte gene expression profile clinically stratifies patients with recent-onset type 1 diabetes.

ABSTRACT: Novel biomarkers of disease progression after type 1 diabetes onset are needed. We profiled peripheral blood (PB) monocyte gene expression in six healthy subjects and 16 children with type 1 diabetes diagnosed ∼3 months previously and analyzed clinical features from diagnosis to 1 year. Monocyte expression profiles clustered into two distinct subgroups, representing mild and severe deviation from healthy control subjects, along the same continuum. Patients with strongly divergent monocyte gene expression had significantly higher insulin dose-adjusted HbA(1c) levels during the first year, compared with patients with mild deviation. The diabetes-associated expression signature identified multiple perturbations in pathways controlling cellular metabolism and survival, including endoplasmic re

SUBMITTER: Irvine KM 

PROVIDER: S-EPMC3331753 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature