Observational cohort study of the safety of digoxin use in women with heart failure.

ABSTRACT:

Objectives

This study aims to assess whether digoxin has a different effect on mortality risk for women than it does for men in patients with heart failure (HF).

Design

This study uses the UK-based The Health Information Network population database in a cohort study of the impact of digoxin exposure on mortality for men and women who carry the diagnosis of HF. Digoxin exposure was assessed based on prescribing data. Multivariable Cox proportional hazards models were used to assess whether there was an interaction between sex and digoxin affecting mortality hazard.

Setting

The setting was primary care outpatient practices.

Participants

The study cohort consisted of 17 707 men and 19 227 women with the diagnosis of HF who contributed only time without digoxin exp

SUBMITTER: Flory JH 

PROVIDER: S-EPMC3332247 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature