Autosomal recessive causes likely in early-onset Alzheimer disease.

ABSTRACT:

Objectives

To determine the genetic contribution to non-autosomal dominant early-onset Alzheimer disease (EOAD) (onset age ≤60 years) cases and identify the likely mechanism of inheritance in those cases.

Design

A liability threshold model of disease was used to estimate heritability of EOAD and late-onset Alzheimer disease (AD) using concordance for AD among parent-offspring pairs.

Setting

The Uniform Data Set, whose participants were collected from 32 US Alzheimer's Disease Centers, maintained by the National Alzheimer's Coordinating Center.

Participants

Individuals with probable AD and detailed parental history (n = 5370).

Main outcome measures

The concordance among relatives and heritability of EOAD and late-onset AD.

Results

For late-onset AD

SUBMITTER: Wingo TS 

PROVIDER: S-EPMC3332307 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature