Design, synthesis, and biological action of 20R-hydroxyvitamin D3.

ABSTRACT: The non-naturally occurring 20R epimer of 20-hydroxyvitamin D3 is synthesized based on chemical design and hypothesis. The 20R isomer is separated by semipreparative HPLC, and its structure is characterized. A comparison of 20R isomer to its 20S counterpart in biological evaluation demonstrates that they have different behaviors in antiproliferative and metabolic studies.

SUBMITTER: Lu Y 

PROVIDER: S-EPMC3332540 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature