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Genetic copy number variants in myocardial infarction patients with hyperlipidemia.


ABSTRACT: BACKGROUND: Cardiovascular disease is the chief cause of death in Taiwan and many countries, of which myocardial infarction (MI) is the most serious condition. Hyperlipidemia appears to be a significant cause of myocardial infarction, because it causes atherosclerosis directly. In recent years, copy number variation (CNV) has been analyzed in genomewide association studies of complex diseases. In this study, CNV was analyzed in blood samples and SNP arrays from 31 myocardial infarction patients with hyperlipidemia. RESULTS: We identified seven CNV regions that were associated significantly with hyperlipidemia and myocardial infarction in our patients through multistage analysis (P<0.001), at 1p21.3, 1q31.2 (CDC73), 1q42.2 (DISC1), 3p21.31 (CDCP1), 10q11.21 (RET) 12p12.3 (PIK3C2G) and 16q23.3 (CDH13), respectively. In particular, the CNV region at 10q11.21 was examined by quantitative real-time PCR, the results of which were consistent with microarray findings. CONCLUSIONS: Our preliminary results constitute an alternative method of evaluating the relationship between CNV regions and cardiovascular disease. These susceptibility CNV regions may be used as biomarkers for early-stage diagnosis of hyperlipidemia and myocardial infarction, rendering them valuable for further research and discussion.

SUBMITTER: Shia WC 

PROVIDER: S-EPMC3333183 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature

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Genetic copy number variants in myocardial infarction patients with hyperlipidemia.

Shia Wei-Chung WC   Ku Tien-Hsiung TH   Tsao Yu-Ming YM   Hsia Chien-Hsun CH   Chang Yung-Ming YM   Huang Ching-Hui CH   Chung Yeh-Ching YC   Hsu Shih-Lan SL   Liang Kae-Woei KW   Hsu Fang-Rong FR  

BMC genomics 20111130


<h4>Background</h4>Cardiovascular disease is the chief cause of death in Taiwan and many countries, of which myocardial infarction (MI) is the most serious condition. Hyperlipidemia appears to be a significant cause of myocardial infarction, because it causes atherosclerosis directly. In recent years, copy number variation (CNV) has been analyzed in genomewide association studies of complex diseases. In this study, CNV was analyzed in blood samples and SNP arrays from 31 myocardial infarction pa  ...[more]

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