The association of Toll-like receptor 4 gene polymorphisms with the development of emphysema in Japanese subjects: a case control study.

ABSTRACT:

Background

The principal role of Toll-like receptor 4 (TLR4) is the induction of immune responses to lipopolysaccharides. Previously, mice deficient in the TLR4 gene exhibited up-regulation of the NADPH oxidase system in the lungs. This resulted in increased oxidant generation and elastolytic activity, which led to pulmonary emphysema. It was suggested that TLR4 might maintain constitutive lung integrity by modulating oxidant generation. We investigated whether single nucleotide polymorphisms (SNPs) in the TLR4 gene were associated with the emphysema phenotype in Japanese subjects with chronic obstructive pulmonary disease (COPD).

Results

Seven SNPs in the TLR4 gene (rs10759930, rs1927914, rs12377632, rs2149356, rs11536889, rs7037117, and rs7045953) were genotyped with allel

SUBMITTER: Ito M 

PROVIDER: S-EPMC3333474 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature