The draft genome of the carcinogenic human liver fluke Clonorchis sinensis.

ABSTRACT:

Background

Clonorchis sinensis is a carcinogenic human liver fluke that is widespread in Asian countries. Increasing infection rates of this neglected tropical disease are leading to negative economic and public health consequences in affected regions. Experimental and epidemiological studies have shown a strong association between the incidence of cholangiocarcinoma and the infection rate of C. sinensis. To aid research into this organism, we have sequenced its genome.

Results

We combined de novo sequencing with computational techniques to provide new information about the biology of this liver fluke. The assembled genome has a total size of 516 Mb with a scaffold N50 length of 42 kb. Approximately 16,000 reliable protein-coding gene models were predicted. Genes for the com

SUBMITTER: Wang X 

PROVIDER: S-EPMC3333777 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature