Depot-specific differences and insufficient subcutaneous adipose tissue angiogenesis in human obesity.

ABSTRACT:

Background

Adipose tissue expands in response to excess caloric intake, but individuals prone to deposit visceral instead of subcutaneous adipose tissue have higher risk of metabolic disease. The role of angiogenesis in the expandability of human adipose tissue depots is unknown. The objective of this study was to measure angiogenesis in visceral and subcutaneous adipose tissue and to establish whether there is a relationship between obesity, metabolic status, and the angiogenic properties of these depots.

Methods and results

Angiogenic capacity was determined by quantifying capillary branch formation from human adipose tissue explants embedded in Matrigel, and capillary density was assessed by immunohistochemistry. Subcutaneous adipose tissue had a greater angiogenic capaci

SUBMITTER: Gealekman O 

PROVIDER: S-EPMC3334340 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature