Vitamin D dependent effects of APOA5 polymorphisms on HDL cholesterol.

ABSTRACT:

Objectives

Vitamin D and serum lipid levels are risk factors for cardiovascular disease. We sought to determine if vitamin D (25OHD) interacts at established lipid loci potentially explaining additional variance in lipids.

Methods

1060 individuals from Utah families were used to screen 14 loci for SNPs potentially interacting with dietary 25OHD on lipid levels. Identified putative interactions were evaluated for (1) greater effect size in subsamples with winter measures, (2) replication in an independent sample, and (3) lack of gene-environment interaction for other correlated dietary factors. Maximum likelihood models were used to evaluate interactions. The replicate sample consisted of 2890 individuals from the Family Heart Study. Putative 25OHD receptor binding site modif

SUBMITTER: Shirts BH 

PROVIDER: S-EPMC3334480 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature