Composite effects of gene determinants on the translation speed and density of ribosomes.

ABSTRACT:

Background

Translation is a central process of life, and its regulation is crucial for cell growth. In this article, focusing on two model organisms, Escherichia coli and Saccharomyces cerevisiae, we study how three major local features of a gene's coding sequence (its adaptation to the tRNA pool, its amino acid charge, and its mRNA folding energy) affect its translation elongation.

Results

We find that each of these three different features has a non-negligible distinct correlation with the speed of translation elongation. In addition, each of these features might contribute independently to slowing down ribosomal speed at the beginning of genes, which was suggested in previous studies to improve ribosomal allocation and the cost of translation, and to decrease ribosomal ja

SUBMITTER: Tuller T 

PROVIDER: S-EPMC3334596 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature