The relationship between proteome size, structural disorder and organism complexity.

ABSTRACT:

Background

Sequencing the genomes of the first few eukaryotes created the impression that gene number shows no correlation with organism complexity, often referred to as the G-value paradox. Several attempts have previously been made to resolve this paradox, citing multifunctionality of proteins, alternative splicing, microRNAs or non-coding DNA. As intrinsic protein disorder has been linked with complex responses to environmental stimuli and communication between cells, an additional possibility is that structural disorder may effectively increase the complexity of species.

Results

We revisited the G-value paradox by analyzing many new proteomes whose complexity measured with their number of distinct cell types is known. We found that complexity and proteome size measured b

SUBMITTER: Schad E 

PROVIDER: S-EPMC3334615 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature