Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights.

ABSTRACT:

Background

Transcription factors (TFs) play a central role in regulating gene expression by interacting with cis-regulatory DNA elements associated with their target genes. Recent surveys have examined the DNA binding specificities of most Saccharomyces cerevisiae TFs, but a comprehensive evaluation of their data has been lacking.

Results

We analyzed in vitro and in vivo TF-DNA binding data reported in previous large-scale studies to generate a comprehensive, curated resource of DNA binding specificity data for all characterized S. cerevisiae TFs. Our collection comprises DNA binding site motifs and comprehensive in vitro DNA binding specificity data for all possible 8-bp sequences. Investigation of the DNA binding specificities within the basic leucine zipper (bZIP) and VHT

SUBMITTER: Gordan R 

PROVIDER: S-EPMC3334620 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature