Ontology highlight
ABSTRACT:
SUBMITTER: Berndt H
PROVIDER: S-EPMC3334704 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
RNA (New York, N.Y.) 20120322 5
Small nucleolar and small Cajal body RNAs (snoRNAs and scaRNAs) of the H/ACA box and C/D box type are generated by exonucleolytic shortening of longer precursors. Removal of the last few nucleotides at the 3' end is known to be a distinct step. We report that, in human cells, knock-down of the poly(A) specific ribonuclease (PARN), previously implicated only in mRNA metabolism, causes the accumulation of oligoadenylated processing intermediates of H/ACA box but not C/D box RNAs. In agreement with ...[more]