IL17A genetic variation is associated with altered susceptibility to Gram-positive infection and mortality of severe sepsis.

ABSTRACT:

Introduction

Interleukin 17A (IL17A) plays a key role in host defense against microbial infection including Gram-positive bacteria. Genetic factors contribute to the host defense, but the role of IL17A single nucleotide polymorphisms (SNPs) has not yet been investigated in severe sepsis. Therefore, we hypothesized that SNPs in the IL17A gene alter susceptibility to infection and clinical outcome of severe sepsis.

Methods

We tested for the association of IL17A SNPs with susceptibility to infection and clinical outcome of severe sepsis using two cohorts of European ancestry (derivation cohort, St Paul's Hospital (SPH), n = 679; validation cohort, Vasopressin and Septic Shock Trial (VASST), n = 517). The primary outcome variable was susceptibility to Gram-positive bacterial inf

SUBMITTER: Nakada TA 

PROVIDER: S-EPMC3334805 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature