Continuous controlled-infusion of hypertonic saline solution in traumatic brain-injured patients: a 9-year retrospective study.

ABSTRACT:

Introduction

Description of a continuous hypertonic saline solution (HSS) infusion using a dose-adaptation of natremia in traumatic brain injured (TBI) patients with refractory intracranial hypertension (ICH).

Methods

We performed a single-center retrospective study in a surgical intensive care unit of a tertiary hospital. Fifty consecutive TBI patients with refractory ICH treated with continuous HSS infusion adapted to a target of natremia. In brief, a physician set a target of natremia adapted to the evolution of intracranial pressure (ICP). Flow of NaCl 20% was a priori calculated according to natriuresis, and the current and target natremia that were assessed every 4 hours.

Results

The HSS infusion was initiated for a duration of 7 (5 to 10) (8 ± 4) days. ICP decr

SUBMITTER: Roquilly A 

PROVIDER: S-EPMC3334811 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature