Functional variant in the autophagy-related 5 gene promotor is associated with childhood asthma.

ABSTRACT:

Rationale and objective

Autophagy is a cellular process directed at eliminating or recycling cellular proteins. Recently, the autophagy pathway has been implicated in immune dysfunction, the pathogenesis of inflammatory disorders, and response to viral infection. Associations between two genes in the autophagy pathway, ATG5 and ATG7, with childhood asthma were investigated.

Methods

Using genetic and experimental approaches, we examined the association of 13 HapMap-derived tagging SNPs in ATG5 and ATG7 with childhood asthma in 312 asthmatic and 246 non-allergic control children. We confirmed our findings by using independent cohorts and imputation analysis. Finally, we evaluated the functional relevance of a disease associated SNP.

Measurements and main results

We demo

SUBMITTER: Martin LJ 

PROVIDER: S-EPMC3335039 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature