Engaging neuroscience to advance translational research in brain barrier biology.

ABSTRACT: The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and--when barrier integrity is impaired--in the pathology of many common CNS disorders such as Alzheimer's disease, Parkinson's disease and stroke.

SUBMITTER: Neuwelt EA 

PROVIDER: S-EPMC3335275 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature