Implementation of the exception from informed consent regulations in a large multicenter emergency clinical trials network: the RAMPART experience.

ABSTRACT: Clinical trials investigating therapies for acutely and critically ill and injured patients in the earliest phases of treatment often can only be performed under regulations allowing for exception from informed consent (EFIC) for emergency research. Implementation of these regulations in multicenter clinical trials involves special challenges and opportunities. The Rapid Anticonvulsant Medication Prior to Arrival Trial (RAMPART), the first EFIC trial conducted by the Neurological Emergencies Treatment Trials (NETT) network, combined centralized resources and coordination with retention of local control and flexibility to facilitate compliance with the EFIC regulations. Specific methods used by the NETT included common tools for community consultation and public disclosure, sharing of exper

SUBMITTER: Silbergleit R 

PROVIDER: S-EPMC3335290 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature