A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex.

ABSTRACT:

Background

Recent genome-wide association studies (GWAS) have identified several novel loci that reproducibly associate with coronary artery disease (CAD) and/or myocardial infarction risk. However, known common CAD risk variants explain only 10% of the predicted genetic heritability of the disease, suggesting that important genetic signals remain to be discovered.

Methods and results

We performed a discovery meta-analysis of 5 GWAS involving 13 949 subjects (7123 cases, 6826 control subjects) imputed at approximately 5 million single nucleotide polymorphisms, using pilot 1000 Genomes-based haplotypes. Promising loci were followed up in an additional 5 studies with 11 032 subjects (5211 cases, 5821 control subjects). A novel CAD locus on chromosome 6p21.3 in the major histoc

SUBMITTER: Davies RW 

PROVIDER: S-EPMC3335297 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature