Pax2 regulates a fadd-dependent molecular switch that drives tissue fusion during eye development.

ABSTRACT: Tissue fusion is an essential morphogenetic mechanism in development, playing a fundamental role in developing neural tube, palate and the optic fissure. Disruption of genes associated with the tissue fusion can lead to congenital malformations, such as spina bifida, cleft lip/palate and ocular coloboma. For instance, the Pax2 transcription factor is required for optic fissure closure, although the mechanism of Pax2 action leading to tissue fusion remains elusive. This lack of information defining how transcription factors drive tissue morphogenesis at the cellular level is hampering new treatments options. Through loss- and gain-of-function analysis, we now establish that pax2 in combination with vax2 directly regulate the fas-associated death domain (fadd) gene. In the presence of fadd,

SUBMITTER: Viringipurampeer IA 

PROVIDER: S-EPMC3335318 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature