Effect of filarial infection on serum inflammatory and atherogenic biomarkers in coronary artery disease (CURES-121).

ABSTRACT: Helminth infections can potentially confer protection against metabolic disorders, possibly through immunomodulation. In this study, the baseline prevalence of lymphatic filariasis (LF) among subjects without (N = 236) and with (N = 217) coronary artery disease (CAD) was examined as part of the Chennai Urban Rural Epidemiological Study (CURES). The prevalence of LF was not significantly different between CAD(-) and CAD(+) subjects. The LF antigen load and antibody levels indicated comparable levels of infection and exposure between the groups. Within the CAD group, LF(+) and LF(-) subjects had no significant difference in the intimal medial thickness and high-sensitivity C-reactive protein values. However, LF infection was associated with augmented levels of tumor necrosis factor-α and int

SUBMITTER: Aravindhan V 

PROVIDER: S-EPMC3335688 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature