Comparative analysis of the heptahelical transmembrane bundles of G protein-coupled receptors.

ABSTRACT:

Background

G protein-coupled receptors represent a large family of eukaryotic membrane proteins, and are involved in almost all physiological processes in humans. Recent advances in the crystallographic study of these receptors enable a detailed comparative analysis of the commonly shared heptahelical transmembrane bundle. Systematic comparison of the bundles from a variety of receptors is indispensable for understanding not only of the structural diversification optimized for the binding of respective ligands but also of the structural conservation required for the common mechanism of activation accompanying the interaction changes among the seven helices.

Methodology/principal findings

We have examined the bundles of 94 polypeptide chains from almost all available structur

SUBMITTER: Okada T 

PROVIDER: S-EPMC3335790 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature