Segregation of regulatory polymorphisms with effects on the gluteus medius transcriptome in a purebred pig population.

ABSTRACT:

Background

The main goal of the present study was to analyse the genetic architecture of mRNA expression in muscle, a tissue with an outmost economic importance for pig breeders. Previous studies have used F(2) crosses to detect porcine expression QTL (eQTL), so they contributed with data that mostly represents the between-breed component of eQTL variation. Herewith, we have analysed eQTL segregation in an outbred Duroc population using two groups of animals with divergent fatness profiles. This approach is particularly suitable to analyse the within-breed component of eQTL variation, with a special emphasis on loci involved in lipid metabolism.

Methodology/principal findings

GeneChip Porcine Genome arrays (Affymetrix) were used to determine the mRNA expression levels of glu

SUBMITTER: Canovas A 

PROVIDER: S-EPMC3335821 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature