Epigenetic silencing of HNF1A associates with changes in the composition of the human plasma N-glycome.

ABSTRACT: Protein glycosylation is a ubiquitous modification that affects the structure and function of proteins. Our recent genome wide association study identified transcription factor HNF1A as an important regulator of plasma protein glycosylation. To evaluate the potential impact of epigenetic regulation of HNF1A on protein glycosylation we analyzed CpG methylation in 810 individuals. The association between methylation of four CpG sites and the composition of plasma and IgG glycomes was analyzed. Several statistically significant associations were observed between HNF1A methylation and plasma glycans, while there were no significant associations with IgG glycans. The most consistent association with HNF1A methylation was observed with the increase in the proportion of highly branched glycans in

SUBMITTER: Zoldos V 

PROVIDER: S-EPMC3335910 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature