Growth differences between North American and European children at risk for type 1 diabetes.

ABSTRACT:

Aim

To evaluate the relationships between early growth and regional variations in type 1 diabetes (T1D) incidence in an international cohort of children with familial and genetic risk for T1D.

Methods

Anthropometric indices between birth to 5 yr of age were compared among regions and T1D proband in 2160 children participating in the Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk study.

Results

Children in Northern Europe had the highest weight z-score between birth to 12 months of age, while those in Southern Europe and U.S.A. had the lowest weight and length/height z-scores at most time points (p < 0.005 to p < 0.001). Few differences in z-score values for weight, height, and body mass index were found by maternal T1D status. Using Int

SUBMITTER: Nucci AM 

PROVIDER: S-EPMC3335929 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature