Silent intralesional microhemorrhage as a risk factor for brain arteriovenous malformation rupture.

ABSTRACT:

Background and purpose

We investigated whether brain arteriovenous malformation silent intralesional microhemorrhage, that is, asymptomatic bleeding in the nidal compartment, might serve as a marker for increased risk of symptomatic intracranial hemorrhage (ICH). We evaluated 2 markers to assess the occurrence of silent intralesional microhemorrhage: neuroradiological assessment of evidence of old hemorrhage-imaging evidence of bleeding before the outcome events-and hemosiderin positivity in hematoxylin and eosin-stained paraffin block sections.

Methods

We identified cases from our brain arteriovenous malformation database with recorded neuroradiological data or available surgical paraffin blocks. Using 2 end points, index ICH or new ICH after diagnosis (censored at treatmen

SUBMITTER: Guo Y 

PROVIDER: S-EPMC3335931 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature