Alkenenitrile Transmissive Olefination: Synthesis of the Putative Lignan "Morinol I"

ABSTRACT: Grignard reagents trigger an addition-elimination with α'-hydroxy acrylonitriles to selectively generate Z-alkenenitriles. The modular assembly of Z-alkenenitriles from a Grignard reagent, acrylonitrile, and an aldehyde is ideal for stereoselectively synthesizing alkenes as illustrated in the synthesis of the putative lignan "morinol I."

SUBMITTER: Fleming FF 

PROVIDER: S-EPMC3336159 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature