The instrumented fetal sheep as a model of cerebral white matter injury in the premature infant.

ABSTRACT: Despite advances in neonatal intensive care, survivors of premature birth remain highly susceptible to unique patterns of developmental brain injury that manifest as cerebral palsy and cognitive-learning disabilities. The developing brain is particularly susceptible to cerebral white matter injury related to hypoxia-ischemia. Cerebral white matter development in fetal sheep shares many anatomical and physiological similarities with humans. Thus, the fetal sheep has provided unique experimental access to the complex pathophysiological processes that contribute to injury to the human brain during successive periods in development. Recent refinements have resulted in models that replicate major features of acute and chronic human cerebral injury and have provided access to complex clinically

SUBMITTER: Back SA 

PROVIDER: S-EPMC3337024 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature