Using modeling to help understand vaginal microbicide functionality and create better products.

ABSTRACT: A summary is presented of a range of mathematical models that relate to topical microbicidal molecules, applied vaginally to inhibit HIV transmission. These models contribute to the fundamental understanding of the functioning of those molecules, as introduced in different delivery systems. They also provide computational tools that can be employed in the practical design and evaluation of vaginal microbicide products. Mathematical modeling can be implemented, using stochastic principles, to understand the probability of infection by sexually transmitted HIV virions. This provides a frame of reference for the deterministic models of the various processes that underlie HIV transmission and its inhibition, including: the temporal and spatial history of HIV migration from semen to vaginal epi

SUBMITTER: Katz DF 

PROVIDER: S-EPMC3337038 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature