Ontology highlight
ABSTRACT:
SUBMITTER: Yang X
PROVIDER: S-EPMC3337150 | biostudies-literature | 2012 Jan-Feb
REPOSITORIES: biostudies-literature
Virulence 20120101 1
Generation of a live attenuated vaccine for bacterial pathogens often requires prior knowledge of the pathogen's virulence factors. We hypothesized an alternative approach of heterologous gene expression would make a wild-type (wt) pathogen more susceptible to host cell killing, thus, resulting in immunization. As proof of concept, the heterologous expression of enterotoxigenic E. coli (ETEC) colonization factor antigen I (CFA/I) was tested to attenuate Salmonella. The overexpression of CFA/I re ...[more]