Logical Gene Ontology Annotations (GOAL): exploring gene ontology annotations with OWL.

ABSTRACT:

Motivation

Ontologies such as the Gene Ontology (GO) and their use in annotations make cross species comparisons of genes possible, along with a wide range of other analytical activities. The bio-ontologies community, in particular the Open Biomedical Ontologies (OBO) community, have provided many other ontologies and an increasingly large volume of annotations of gene products that can be exploited in query and analysis. As many annotations with different ontologies centre upon gene products, there is a possibility to explore gene products through multiple ontological perspectives at the same time. Questions could be asked that link a gene product's function, process, cellular location, phenotype and disease. Current tools, such as AmiGO, allow exploration of genes based on their

SUBMITTER: Jupp S 

PROVIDER: S-EPMC3337258 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature