Crystal structures from the Plasmodium peroxiredoxins: new insights into oligomerization and product binding.

ABSTRACT:

Background

Plasmodium falciparum is the protozoan parasite primarily responsible for more than one million malarial deaths, annually, and is developing resistance to current therapies. Throughout its lifespan, the parasite is subjected to oxidative attack, so Plasmodium antioxidant defences are essential for its survival and are targets for disease control.

Results

To further understand the molecular aspects of the Plasmodium redox system, we solved 4 structures of Plasmodium peroxiredoxins (Prx). Our study has confirmed PvTrx-Px1 to be a hydrogen peroxide (H2O2)-sensitive peroxiredoxin. We have identified and characterized the novel toroid octameric oligomer of PyTrx-Px1, which may be attributed to the interplay of several factors including: (1) the orientation of the conse

SUBMITTER: Qiu W 

PROVIDER: S-EPMC3337327 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature