Influence of severity of anemia on clinical findings in infants with sickle cell anemia: analyses from the BABY HUG study.

ABSTRACT:

Background

Clinical complications of sickle cell anemia begin in infancy. BABY HUG (ClinicalTrials.gov, NCT00006400) was a NHLBI-NICHD supported randomized phase III placebo-controlled trial of hydroxyurea (HU) in infants (recruited at 9-18 months) unselected for clinical severity with sickle cell anemia. This secondary analysis of data from BABY HUG examines the influence of anemia on the incidence of sickle cell related complications, and the impact of hydroxyurea therapy in altering these events by comparing children with lower (<25th percentile) and higher (>75th percentile) hemoglobin concentrations at study entry.

Procedure

Infants were categorized by: (1) age-adjusted hemoglobin quartiles as determined by higher (Hi) and lower (Lo) hemoglobin concentrations at study e

SUBMITTER: Lebensburger JD 

PROVIDER: S-EPMC3337342 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature