Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis.

ABSTRACT: Atopic dermatitis (AD) has long been associated with Staphylococcus aureus skin colonization or infection and is typically managed with regimens that include antimicrobial therapies. However, the role of microbial communities in the pathogenesis of AD is incompletely characterized. To assess the relationship between skin microbiota and disease progression, 16S ribosomal RNA bacterial gene sequencing was performed on DNA obtained directly from serial skin sampling of children with AD. The composition of bacterial communities was analyzed during AD disease states to identify characteristics associated with AD flares and improvement post-treatment. We found that microbial community structures at sites of disease predilection were dramatically different in AD patients compared with controls. M

SUBMITTER: Kong HH 

PROVIDER: S-EPMC3337431 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature