Conserved Motifs and Prediction of Regulatory Modules in Caenorhabditis elegans.

ABSTRACT: Transcriptional regulation, a primary mechanism for controlling the development of multicellular organisms, is carried out by transcription factors (TFs) that recognize and bind to their cognate binding sites. In Caenorhabditis elegans, our knowledge of which genes are regulated by which TFs, through binding to specific sites, is still very limited. To expand our knowledge about the C. elegans regulatory network, we performed a comprehensive analysis of the C. elegans, Caenorhabditis briggsae, and Caenorhabditis remanei genomes to identify regulatory elements that are conserved in all genomes. Our analysis identified 4959 elements that are significantly conserved across the genomes and that each occur multiple times within each genome, both hallmarks of functional regulatory sites. Our mot

SUBMITTER: Zhao G 

PROVIDER: S-EPMC3337475 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature