Association of the resistin gene promoter region polymorphism with Kawasaki disease in Chinese children.

ABSTRACT:

Objectives

The -420 C > G polymorphism located in the resistin gene (RETN) promoter has recently been suggested to play a potential role in proinflammatory conditions and cardiovascular disease. This study investigated the association of the RETN promoter polymorphism with Kawasaki disease (KD) and its clinical parameters in Chinese children.

Methods

We compared patients with complete KD to incomplete KD children. Genotyping of the RETN promoter polymorphism was performed using MassARRAY system, and serum resistin levels were estimated using the sandwich enzyme immunoassay method.

Results

There was no significant difference in RETN (-420 C > G) genotypes between KD and control groups. However, the frequency of the G allele was higher in iKD patients than in cKD childr

SUBMITTER: Liu R 

PROVIDER: S-EPMC3337635 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature