PINALOG: a novel approach to align protein interaction networks--implications for complex detection and function prediction.

ABSTRACT:

Motivation

Analysis of protein-protein interaction networks (PPINs) at the system level has become increasingly important in understanding biological processes. Comparison of the interactomes of different species not only provides a better understanding of species evolution but also helps with detecting conserved functional components and in function prediction. Method and

Results

Here we report a PPIN alignment method, called PINALOG, which combines information from protein sequence, function and network topology. Alignment of human and yeast PPINs reveals several conserved subnetworks between them that participate in similar biological processes, notably the proteasome and transcription related processes. PINALOG has been tested for its power in protein complex prediction

SUBMITTER: Phan HT 

PROVIDER: S-EPMC3338015 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature